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MARCH5 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72646Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MARCH5. AA range:21-70Source:
Polyclonal, RabbitGene Name:
MARCH5Dilution:
WB 1:500-2000 Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
- Immunofluorescence analysis of Hela cell. 1,MARCH5 Polyclonal Antibody(green) was diluted at 1:200(4° overnight). 2, Goat Anti Rabbit Alexa Fluor 488 Catalog:RS3211 was diluted at 1:1000(room temperature, 50min). 3 DAPI(blue) 10min.
Background:
membrane associated ring-CH-type finger 5(MARCH5) Homo sapiens MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008],Protein Name:
E3 ubiquitin-protein ligase MARCH5Human Gene Id:
54708Human Swiss Prot No:
Q9NX47Mouse Gene Id:
69104Mouse Swiss Prot No:
Q3KNM2Specificity:
MARCH5 Polyclonal Antibody detects endogenous levels of 40607 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MARCH5; RNF153; E3 ubiquitin-protein ligase MARCH5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; MARCH-V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153MolecularWeight(Da):
31232Observed Band(KD):
37Function:
domain:The RING-CH-type zinc finger domain is required for E3 ligase activity.,function:Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology. Promotes ubiquitination of DRP1. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-CH-type zinc finger.,subunit:Interacts with MTFN2 and ubiquitinated forms of DRP1.,Subcellular Location:
mitochondrial outer membrane,endoplasmic reticulum,endoplasmic reticulum membrane,membrane,integral component of membrane,Expression:
B-cell,Colon,Skin,
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Catalog Number
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