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Manic Fringe Polyclonal Antibody
Datasheet
Catalog Number:
E20-72634Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MFNG. AA range:61-110Source:
Polyclonal, RabbitGene Name:
MFNGDilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
- Western blot analysis of the lysates from HepG2 cells using MFNG antibody.
Background:
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase(MFNG) Homo sapiens This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009],Protein Name:
Beta-1,3-N-acetylglucosaminyltransferase manic fringeHuman Gene Id:
4242Human Swiss Prot No:
O00587Mouse Gene Id:
17305Mouse Swiss Prot No:
O09008Specificity:
Manic Fringe Polyclonal Antibody detects endogenous levels of Manic Fringe protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MFNG; Beta-1; 3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseMolecularWeight(Da):
36202Observed Band(KD):
38Function:
catalytic activity:Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.,function:Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.,online information:Beta-1,3-N-acetylglucosaminyltransferase manic fringe,online information:GlycoGene database,similarity:Belongs to the glycosyltransferase 31 family.,Subcellular Location:
extracellular space,membrane,integral component of Golgi membrane,Expression:
Lymph,
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