MAN1B1 Polyclonal Antibody

Name: MAN1B1 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-72633
Price: 225 USD
Availability: InStock

E20-72633Cite ID: EN0052766Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight(Da):79580

Protein NameEndoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

Human Gene Id11253

Human Swiss Prot NoQ9UKM7

Mouse Swiss Prot NoA2AJ15

SpecificityMAN1B1 Polyclonal Antibody detects endogenous levels of MAN1B1 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameMAN1B1; Endoplasmic reticulum mannosyl-oligosaccharide 1; 2-alpha-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1

Observed Band(KD)80

Functioncatalytic activity:Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).,cofactor:Calcium.,enzyme regulation:Inhibited by both 1-deoxymannojirimycin and kifunensine.,function:Involved in the maturation of Asn-linked oligosaccharides. Trim a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2). The only product is the Man(8)GlcNAc(2) isomer B, the form lacking the middle-arm terminal alpha 1,2-mannose. It may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation.,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyl hydrolase 47 family.,tissue specificity:Widely expressed.,

Subcellular Locationendoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,membrane,integral component of membrane,endoplasmic reticulum quality control compartment,extracellular vesicle,

ExpressionBrain,Fetal brain,Liver,Lung,Placenta,Testis,Uterus,Whole embryo,,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from MAN1B1 . at AA range: 100-180

Gene NameMAN1B1

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Backgroundmannosidase alpha class 1B member 1(MAN1B1) Homo sapiens This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-72633-Conjugate. Price: $485 / Size: 100μl.

E20-72633-FITC$485 / 100μlE20-72633-Biotin$485 / 100μlE20-72633-HRP$485 / 100μlE20-72633-AP$485 / 100μlE20-72633-AF350$485 / 100μlE20-72633-AF405M$485 / 100μlE20-72633-AF488$485 / 100μlE20-72633-AF514$485 / 100μlE20-72633-AF532$485 / 100μlE20-72633-AF555$485 / 100μlE20-72633-AF568$485 / 100μlE20-72633-AF405S$485 / 100μlE20-72633-AF405L$485 / 100μlE20-72633-AF546$485 / 100μlE20-72633-AF594$485 / 100μlE20-72633-AF610$485 / 100μlE20-72633-AF635$485 / 100μlE20-72633-AF647$485 / 100μlE20-72633-AF680$485 / 100μlE20-72633-AF700$485 / 100μlE20-72633-AF750$485 / 100μlE20-72633-AF790$485 / 100μlE20-72633-APC$485 / 100μlE20-72633-PE$485 / 100μlE20-72633-Cy3$485 / 100μlE20-72633-Cy5$485 / 100μlE20-72633-Cy5.5$485 / 100μlE20-72633-Cy7$485 / 100μlE20-72633-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.