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Cell Signal Transduction Research Antibodies
Mad 4 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight23528 Da
Protein NameMax dimerization protein 4
Human Gene Id10608
Human Swiss Prot NoQ14582
Mouse Swiss Prot NoQ60948
SpecificityMad 4 Polyclonal Antibody detects endogenous levels of Mad 4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMXD4; BHLHC12; MAD4; Max dimerization protein 4; Max dimerizer 4; Class C basic helix-loop-helix protein 12; bHLHc12; Max-associated protein 4; Max-interacting transcriptional repressor MAD4
Functionfunction:Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17.,
Subcellular Locationnucleus,
ExpressionBrain,Lung,Normal aorta,Spleen,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human MAD4. AA range:10-59
Gene NameMXD4
DilutionImmunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
BackgroundMAX dimerization protein 4(MXD4) Homo sapiens This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-72616-Conjugate. Price: $485 / Size: 100μl.
E20-72616-FITC$485 / 100μlE20-72616-Biotin$485 / 100μlE20-72616-HRP$485 / 100μlE20-72616-AP$485 / 100μlE20-72616-AF350$485 / 100μlE20-72616-AF405M$485 / 100μlE20-72616-AF488$485 / 100μlE20-72616-AF514$485 / 100μlE20-72616-AF532$485 / 100μlE20-72616-AF555$485 / 100μlE20-72616-AF568$485 / 100μlE20-72616-AF405S$485 / 100μlE20-72616-AF405L$485 / 100μlE20-72616-AF546$485 / 100μlE20-72616-AF594$485 / 100μlE20-72616-AF610$485 / 100μlE20-72616-AF635$485 / 100μlE20-72616-AF647$485 / 100μlE20-72616-AF680$485 / 100μlE20-72616-AF700$485 / 100μlE20-72616-AF750$485 / 100μlE20-72616-AF790$485 / 100μlE20-72616-APC$485 / 100μlE20-72616-PE$485 / 100μlE20-72616-Cy3$485 / 100μlE20-72616-Cy5$485 / 100μlE20-72616-Cy5.5$485 / 100μlE20-72616-Cy7$485 / 100μlE20-72616-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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