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mAChR M4 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72613Amount:
100ulMolecular Weight:
53049 DaObserved Band:53 KDApplications:
WB;IF/ICC;ELISAReactivity:
Human;Rat;Mouse;Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CHRM4. AA range:236-285Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using mAChR M4 Polyclonal Antibody
Gene Name:
CHRM4Dilution:
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
Muscarinic acetylcholine receptor M4Human Gene Id:
1132Human Swiss Prot No:
P08173Mouse Gene Id:
12672Mouse Swiss Prot No:
P32211Rat Gene Id:
25111Rat Swiss Prot No:
P08485Specificity:
mAChR M4 Polyclonal Antibody detects endogenous levels of mAChR M4 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CHRM4; Muscarinic acetylcholine receptor M4Background:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008],Function:
function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.Expression:
Brain,
- Immunofluorescence analysis of LOVO cells, using CHRM4 Antibody. The picture on the right is blocked with the synthesized peptide.
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