World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
mAChR M2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight51715DaObserved Band:85KD
Protein NameMuscarinic acetylcholine receptor M2
Human Gene Id1129
Human Swiss Prot NoP08172
Mouse Gene Id243764
Mouse Swiss Prot NoQ9ERZ4
Rat Gene Id81645
Rat Swiss Prot NoP10980
SpecificitymAChR M2 Polyclonal Antibody detects endogenous levels of mAChR M2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCHRM2; Muscarinic acetylcholine receptor M2
Functiondisease:Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD) [MIM:608516]. MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other imp
Subcellular Locationplasma membrane,integral component of plasma membrane,cell junction,dendrite,asymmetric synapse,symmetric synapse,neuronal cell body,axon terminus,synapse,postsynaptic membrane,
ExpressionBrain,Thalamus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CHRM2. AA range:185-234
Gene NameCHRM2
DilutionWestern Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcholinergic receptor muscarinic 2(CHRM2) Homo sapiens The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],
Western blot analysis of lysates from HeLa and MCF-7 cells, using CHRM2 Antibody. The lane on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of LOVO cells, using Antibody. The picture on the right is blocked with synthesized peptide.
Conjugated Antibody
This product is also available conjugated. Format: E20-72612-Conjugate. Price: $485 / Size: 100μl.
E20-72612-FITC$485 / 100μlE20-72612-Biotin$485 / 100μlE20-72612-HRP$485 / 100μlE20-72612-AP$485 / 100μlE20-72612-AF350$485 / 100μlE20-72612-AF405M$485 / 100μlE20-72612-AF488$485 / 100μlE20-72612-AF514$485 / 100μlE20-72612-AF532$485 / 100μlE20-72612-AF555$485 / 100μlE20-72612-AF568$485 / 100μlE20-72612-AF405S$485 / 100μlE20-72612-AF405L$485 / 100μlE20-72612-AF546$485 / 100μlE20-72612-AF594$485 / 100μlE20-72612-AF610$485 / 100μlE20-72612-AF635$485 / 100μlE20-72612-AF647$485 / 100μlE20-72612-AF680$485 / 100μlE20-72612-AF700$485 / 100μlE20-72612-AF750$485 / 100μlE20-72612-AF790$485 / 100μlE20-72612-APC$485 / 100μlE20-72612-PE$485 / 100μlE20-72612-Cy3$485 / 100μlE20-72612-Cy5$485 / 100μlE20-72612-Cy5.5$485 / 100μlE20-72612-Cy7$485 / 100μlE20-72612-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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