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LT-β Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72601

  • Amount:

    100ul

  • Molecular Weight:

    25390 DaObserved Band:22 KD

  • Applications:

    WB;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human TNFC. AA range:181-230

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using LTβR Polyclonal Antibody

  • Gene Name:

    LTB

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Lymphotoxin-beta

  • Human Gene Id:

    4050

  • Human Swiss Prot No:

    Q06643

  • Mouse Gene Id:

    16994

  • Mouse Swiss Prot No:

    P41155

  • Specificity:

    LT-β Polyclonal Antibody detects endogenous levels of LT-β protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    LTB; TNFC; TNFSF3; Lymphotoxin-beta; LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

  • Background:

    Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

  • Function:

    function:Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.,similarity:Belongs to the tumor necrosis factor family.,subunit:Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.,tissue specificity:Spleen and thymus.,

  • Subcellular Location:

    Membrane ; Single-pass type II membrane protein .

  • Expression:

    Spleen and thymus.

  • Immunofluorescence analysis of HeLa cells, using LTBR Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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LT-β Polyclonal Antibody | EnoGene Biotech Co. Ltd