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Lsk Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72595

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized peptide derived from the Internal region of human Lsk.

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MATK

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Background:

    megakaryocyte-associated tyrosine kinase(MATK) Homo sapiens The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Megakaryocyte-associated tyrosine-protein kinase

  • Human Gene Id:

    4145

  • Human Swiss Prot No:

    P42679

  • Mouse Gene Id:

    17179

  • Mouse Swiss Prot No:

    P41242

  • Rat Gene Id:

    60450

  • Rat Swiss Prot No:

    P41243

  • Specificity:

    Lsk Polyclonal Antibody detects endogenous levels of Lsk protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MATK; CTK; HYL; Megakaryocyte-associated tyrosine-protein kinase; CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK

  • MolecularWeight(Da):

    56469

  • Observed Band(KD):

    56

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Expressed in various myeloid cell lines, detected in brain and lung.,

  • Subcellular Location:

    cytosol,extrinsic component of cytoplasmic side of plasma membrane,

  • Expression:

    Brain,Epithelium,Eye,Megakaryocyte,Testis,

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Catalog Number

  • Amount:100ul
  • Price:225$

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