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LRP1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72589

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CD91. AA range:4486-4535

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    LRP1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Western blot analysis of lysates from HepG2 cells, using CD91 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    LDL receptor related protein 1(LRP1) Homo sapiens This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015],

  • Protein Name:

    Prolow-density lipoprotein receptor-related protein 1

  • Human Gene Id:

    4035

  • Human Swiss Prot No:

    Q07954

  • Mouse Gene Id:

    16971

  • Mouse Swiss Prot No:

    Q91ZX7

  • Specificity:

    LRP1 Polyclonal Antibody detects endogenous levels of LRP1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91

  • MolecularWeight(Da):

    504575

  • Observed Band(KD):

    50

  • Function:

    function:Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.,PTM:Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.,PTM:Phosphorylated on serine and threonine residues.,PTM:Phosphorylated on tyrosine residues upon stimulation w

  • Subcellular Location:

    nucleolus,cytoplasm,lysosomal membrane,endosome,plasma membrane,integral component of plasma membrane,clathrin-coated pit,focal adhesion,integral component of membrane,clathrin-coated vesicle,dendrite,endocytic vesicle m

  • Expression:

    Blood,Brain,Liver,Lung,Placenta,Plasma,Prostate,Skin,

  • Western blot analysis of the lysates from HUVECcells using CD91 antibody.

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Catalog Number

  • Amount:100ul
  • Price:225$

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LRP1 Polyclonal Antibody | EnoGene Biotech Co. Ltd