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LOK Polyclonal Antibody
Datasheet
Catalog Number:
E20-72578Amount:
100ulMolecular Weight:
112135 DaObserved Band:120 KDApplications:
WB;ELISA;IHC-pReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human STK10. AA range:491-540Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using LOK Polyclonal Antibody
Gene Name:
STK10Dilution:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000Protein Name:
Serine/threonine-protein kinase 10Human Gene Id:
6793Human Swiss Prot No:
O94804Mouse Swiss Prot No:
O55098Specificity:
LOK Polyclonal Antibody detects endogenous levels of LOK protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
STK10; LOK; Serine/threonine-protein kinase 10; Lymphocyte-oriented kinaseBackground:
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008],Function:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed predominantly in lymphoid organs.,Subcellular Location:
Cell membrane ; Peripheral membrane protein .Expression:
Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.
- Western Blot analysis of HuvEc cells using LOK Polyclonal Antibody
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