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Cell Signal Transduction Research Antibodies
LEKTI Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight120759Da
Protein NameSerine protease inhibitor Kazal-type 5
Human Gene Id11005
Human Swiss Prot NoQ9NQ38
SpecificityLEKTI Polyclonal Antibody detects endogenous levels of LEKTI protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSPINK5; Serine protease inhibitor Kazal-type 5; Lympho-epithelial Kazal-type-related inhibitor; LEKTI
Observed Band(KD)120
Functiondisease:Defects in SPINK5 are the cause of Netherton syndrome (NETH) [MIM:256500]. NETH is an autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration.,domain:Contains at least one active inhibitory domain for trypsin (domain 6).,function:Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia.,online information:SPINK5 mutation db,similarity:Contains 15 Kazal-like domains.,tissue specificity:Highly expressed in the thymus. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal e
Subcellular Locationextracellular region,cytoplasm,endoplasmic reticulum,endoplasmic reticulum membrane,cytosol,cell cortex,perinuclear region of cytoplasm,extracellular exosome,epidermal lamellar body,
ExpressionEpithelium,Foreskin keratinocyte,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human SPINK5. AA range:494-543
Gene NameSPINK5
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundserine peptidase inhibitor, Kazal type 5(SPINK5) Homo sapiens This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-72554-Conjugate. Price: $485 / Size: 100μl.
E20-72554-FITC$485 / 100μlE20-72554-Biotin$485 / 100μlE20-72554-HRP$485 / 100μlE20-72554-AP$485 / 100μlE20-72554-AF350$485 / 100μlE20-72554-AF405M$485 / 100μlE20-72554-AF488$485 / 100μlE20-72554-AF514$485 / 100μlE20-72554-AF532$485 / 100μlE20-72554-AF555$485 / 100μlE20-72554-AF568$485 / 100μlE20-72554-AF405S$485 / 100μlE20-72554-AF405L$485 / 100μlE20-72554-AF546$485 / 100μlE20-72554-AF594$485 / 100μlE20-72554-AF610$485 / 100μlE20-72554-AF635$485 / 100μlE20-72554-AF647$485 / 100μlE20-72554-AF680$485 / 100μlE20-72554-AF700$485 / 100μlE20-72554-AF750$485 / 100μlE20-72554-AF790$485 / 100μlE20-72554-APC$485 / 100μlE20-72554-PE$485 / 100μlE20-72554-Cy3$485 / 100μlE20-72554-Cy5$485 / 100μlE20-72554-Cy5.5$485 / 100μlE20-72554-Cy7$485 / 100μlE20-72554-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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