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Lck Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72547

  • Amount:

    100ul

  • Applications:

    WB;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Lck. AA range:361-410

  • Source:

    Polyclonal, Rabbit

  • Western blot analysis of lysates from 293 cells, treated with serum 15% 10', using Lck Antibody. The lane on the right is blocked with the synthesized peptide.

  • Gene Name:

    LCK

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

  • Background:

    LCK proto-oncogene, Src family tyrosine kinase(LCK) Homo sapiens This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016],

  • Protein Name:

    Tyrosine-protein kinase Lck

  • Human Gene Id:

    3932

  • Human Swiss Prot No:

    P06239

  • Mouse Gene Id:

    16818

  • Mouse Swiss Prot No:

    P06240

  • Rat Gene Id:

    313050

  • Rat Swiss Prot No:

    Q01621

  • Specificity:

    Lck Polyclonal Antibody detects endogenous levels of Lck protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK

  • MolecularWeight(Da):

    58001

  • Observed Band(KD):

    58

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB.,domain:The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation.,enzyme regulation:Inhibited by tyrosine phosphorylation.,function:Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associat

  • Subcellular Location:

    pericentriolar material,immunological synapse,cytosol,plasma membrane,extrinsic component of cytoplasmic side of plasma membrane,membrane raft,extracellular exosome,

  • Expression:

    Blood,Leukemia,Leukemic T-cell,Lymph,Mammary cancer,Periphe,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Lck Polyclonal Antibody | EnoGene Biotech Co. Ltd