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Laminin β-3 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72530

  • Amount:

    100ul

  • Applications:

    IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human LAMB3. AA range:671-720

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    LAMB3

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of lysates from Jurkat cells, using Lck Antibody. The lane on the right is blocked with the phospho peptide.

  • Background:

    laminin subunit beta 3(LAMB3) Homo sapiens The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Laminin subunit beta-3

  • Human Gene Id:

    3914

  • Human Swiss Prot No:

    Q13751

  • Mouse Swiss Prot No:

    Q61087

  • Specificity:

    Laminin β-3 Polyclonal Antibody detects endogenous levels of Laminin β-3 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    LAMB3; LAMNB1; Laminin subunit beta-3; Epiligrin subunit bata; Kalinin B1 chain; Kalinin subunit beta; Laminin B1k chain; Laminin-5 subunit beta; Nicein subunit beta

  • MolecularWeight(Da):

    129572

  • Function:

    disease:Defects in LAMB3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB) [MIM:226700]; also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.,disease:Defects in LAMB3 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.,domain:Domain VI is globular.,doma

  • Subcellular Location:

    extracellular region,laminin-5 complex,

  • Expression:

    Epidermis,Eye,

  • Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using LAMB3 Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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Laminin β-3 Polyclonal Antibody | EnoGene Biotech Co. Ltd