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Laminin α-4 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72522

  • Amount:

    100ul

  • Molecular Weight:

    66408Observed Band:67 KD

  • Applications:

    IF/ICC;WB;IHC-p;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Lamin B1. AA range:26-75

  • Source:

    Polyclonal, Rabbit,IgG

  • Immunofluorescence analysis of Hela cell. 1,Lamin B1 Polyclonal Antibody(red) was diluted at 1:200(4° overnight). GFAP Monoclonal Antibody(5C8)(green) was diluted at 1:200(4° overnight). 2, Goat Anti Rabbit Alexa Fluor 594 Catalog:RS3611 was diluted at 1:1000(room temperature, 50min). Goat Anti Mouse Alexa Fluor 488 Catalog:RS3208 was diluted at 1:1000(room temperature, 50min).

  • Gene Name:

    LMNB1

  • Dilution:

    IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Lamin-B1

  • Human Gene Id:

    4001

  • Human Swiss Prot No:

    P20700

  • Mouse Gene Id:

    16906

  • Mouse Swiss Prot No:

    P14733

  • Rat Gene Id:

    116685

  • Rat Swiss Prot No:

    P70615

  • Specificity:

    Lamin B1 Polyclonal Antibody detects endogenous levels of Lamin B1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    LMNB1; LMN2; LM Da NB; Lamin-B1

  • Background:

    lamin B1(LMNB1) Homo sapiens This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

  • Function:

    disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle

  • Subcellular Location:

    Nucleus lamina .

  • Expression:

    Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,

  • Immunofluorescence analysis of rat-lung tissue. 1,Lamin B1 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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