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KV4.1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72513

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human KCND1. AA range:558-607

  • Source:

    Polyclonal, Rabbit

  • Western blot analysis of lysates from NIH/3T3 cells, using KCND1 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Gene Name:

    KCND1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    potassium voltage-gated channel subfamily D member 1(KCND1) Homo sapiens This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013],

  • Protein Name:

    Potassium voltage-gated channel subfamily D member 1

  • Human Gene Id:

    3750

  • Human Swiss Prot No:

    Q9NSA2

  • Mouse Gene Id:

    16506

  • Mouse Swiss Prot No:

    Q03719

  • Specificity:

    KV4.1 Polyclonal Antibody detects endogenous levels of KV4.1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    KCND1; Potassium voltage-gated channel subfamily D member 1; Voltage-gated potassium channel subunit Kv4.1

  • MolecularWeight(Da):

    71330

  • Observed Band(KD):

    70

  • Function:

    domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.,similarity:Belongs to the potassium channel family. D (Shal) subfamily.,subunit:Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10.,tissue specificity:Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.,

  • Subcellular Location:

    plasma membrane,voltage-gated potassium channel complex,integral component of membrane,dendrite,neuronal cell body,

  • Expression:

    Brain,Embryonic kidney,Heart,Testis,

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Catalog Number

  • Amount:100ul
  • Price:225$

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KV4.1 Polyclonal Antibody | EnoGene Biotech Co. Ltd