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Ku-80 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72502

  • Amount:

    100ul

  • Molecular Weight:

    82705Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;MouseGene Nam:XRCC5
    Protein Nam:X-ray repair cross-complementing protein 5

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Ku80. AA range:683-732

  • Western Blot analysis of various cells using Ku-80 Polyclonal Antibody

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Human Gene Id:

    7520

  • Human Swiss Prot No:

    P13010

  • Mouse Swiss Prot No:

    P27641

  • Specificity:

    Ku-80 Polyclonal Antibody detects endogenous levels of Ku-80 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Sourc:Polyclonal, Rabbit,IgG

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 yearOther Nam:XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair pr

  • Observed Band(KD):

    83

  • Background:

    X-ray repair cross complementing 5(XRCC5) Homo sapiens The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],

  • Function:

    developmental stage:Expression increases during promyelocyte differentiation.,disease:Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86.,domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.,function:Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The Ku p70/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of t

  • Subcellular Location:

    Nucleus . Nucleus, nucleolus . Chromosome .

  • Expression:

    Cervix carcinoma,Coronary artery,Heart,Neuroblastoma,Osteoblast,Thy

  • Immunofluorescence analysis of HeLa cells, using Ku80 Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

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Ku-80 Polyclonal Antibody | EnoGene Biotech Co. Ltd