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KOR-1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72488

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human OPRK1. AA range:321-370

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    OPRK1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of lysates from COS7 cells, using OPRK1 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    opioid receptor kappa 1(OPRK1) Homo sapiens This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016],

  • Protein Name:

    Kappa-type opioid receptor

  • Human Gene Id:

    4986

  • Human Swiss Prot No:

    P41145

  • Mouse Gene Id:

    18387

  • Mouse Swiss Prot No:

    P33534

  • Rat Gene Id:

    29335

  • Rat Swiss Prot No:

    P34975

  • Specificity:

    KOR-1 Polyclonal Antibody detects endogenous levels of KOR-1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1

  • MolecularWeight(Da):

    42645

  • Observed Band(KD):

    48

  • Function:

    function:Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.,online information:Kappa opioid receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SLC9A3R1. Interacts with GABARAPL1.,

  • Subcellular Location:

    plasma membrane,integral component of plasma membrane,integral component of membrane,dendrite,neuron projection,perikaryon,axon terminus,synapse,

  • Expression:

    Brain,Placenta,

  • Western blot analysis of the lysates from HeLa cells using OPRK1 antibody.

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Catalog Number

  • Amount:100ul
  • Price:225$

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KOR-1 Polyclonal Antibody | EnoGene Biotech Co. Ltd