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KIR5.1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72478

  • Amount:

    100ul

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    . The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from mouse Kir5.1. AA range:369-418

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of HeLa cells using KIR5.1 Polyclonal Antibody

  • Gene Name:

    KCNJ16

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Inward rectifier potassium channel 16

  • Human Gene Id:

    16517

  • Human Swiss Prot No:

    Q9NPI9

  • Specificity:

    KIR5.1 Polyclonal Antibody detects endogenous levels of KIR5.1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    KCNJ16; Inward rectifier potassium channel 16; Inward rectifier K(+) channel Kir5.1; Potassium channel; inwardly rectifying subfamily J member 16MolecularWeight: 47936Da

  • Observed Band(KD):

    48

  • Background:

    potassium voltage-gated channel subfamily J member 16(KCNJ16) Homo sapiens Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014],

  • Function:

    function:Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.,tissue specificity:Highly expressed in kidney, pancreas and thyroid gland.,

  • Subcellular Location:

    plasma membrane,integral component of plasma membrane,voltage-gated potassium channel complex,membrane,integral component of membrane,basolateral plasma membrane,

  • Immunofluorescence analysis of HeLa cells, using Kir5.1 Antibody. The picture on the right is blocked with the synthesized peptide.

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