Product Information
Molecular Weight25027Da
Protein NameER lumen protein retaining receptor 3
Human Gene Id11015
Human Swiss Prot NoO43731
Mouse Gene Id105785
Mouse Swiss Prot NoQ8R1L4
SpecificityKDEL Receptor 3 Polyclonal Antibody detects endogenous levels of KDEL Receptor 3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameKDELR3; ER lumen protein retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3
Observed Band(KD)28
Functionfunction:Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.,similarity:Belongs to the ERD2 family.,
Subcellular LocationGolgi membrane,endoplasmic reticulum membrane,integral component of membrane,transport vesicle,
ExpressionCervix,Kidney,Stomach,Synovial cell,
BackgroundKDEL endoplasmic reticulum protein retention receptor 3(KDELR3) Homo sapiens This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alt