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KALIG-1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72448

  • Amount:

    100ul

  • Molecular Weight:

    76112Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human KAL1. AA range:151-200

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using KALIG-1 Polyclonal Antibody

  • Gene Name:

    KAL1

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300

  • Protein Name:

    Anosmin-1

  • Human Gene Id:

    3730

  • Human Swiss Prot No:

    P23352

  • Specificity:

    KALIG-1 Polyclonal Antibody detects endogenous levels of KALIG-1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    KAL1; ADMLX; KAL; KALIG1; Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein

  • Observed Band(KD):

    76

  • Background:

    Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008],

  • Function:

    disease:Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.,function:May be an adhesion-like molecule with anti-protease activity.,PTM:N-glycosylated.,similarity:Contains 1 WAP domain.,similarity:Contains 4 fibronectin type-III domains.,

  • Subcellular Location:

    Cell membrane ; Peripheral membrane protein . Secreted . Proteolytic cleavage may release it from the cell surface into the extracellular space.

  • Expression:

    Expressed in the cerebellum (at protein level).

  • Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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Catalog Number

  • Amount:100ul
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KALIG-1 Polyclonal Antibody | EnoGene Biotech Co. Ltd