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JMY Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72438

  • Amount:

    100ul

  • Molecular Weight:

    71826Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human JMY. AA range:931-980

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using JMY Polyclonal Antibody

  • Gene Name:

    JMY

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

  • Protein Name:

    Junction-mediating and -regulatory protein

  • Human Gene Id:

    133746

  • Human Swiss Prot No:

    Q8N9B5

  • Mouse Gene Id:

    57748

  • Mouse Swiss Prot No:

    Q9QXM1

  • Specificity:

    JMY Polyclonal Antibody detects endogenous levels of JMY protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    JMY; Junction-mediating and -regulatory protein

  • Observed Band(KD):

    130

  • Background:

    function:Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage.,induction:By E2F.,PTM:Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response.,similarity:Contains 1 WH2 domain.,subunit:Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.,

  • Function:

    function:Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage.,induction:By E2F.,PTM:Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response.,similarity:Contains 1 WH2 domain.,subunit:Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.,

  • Subcellular Location:

    Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane . Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (PubMed:30420355

  • Expression:

    Brain,Substantia nigra,

  • Western blot analysis of lysates from COLO cells, using JMY Antibody. The lane on the right is blocked with the synthesized peptide.

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