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JAK1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72425

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human JAK1. AA range:91-140

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    JAK1

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JAK1 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    Janus kinase 1(JAK1) Homo sapiens This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],

  • Protein Name:

    Tyrosine-protein kinase JAK1

  • Human Gene Id:

    3716

  • Human Swiss Prot No:

    P23458

  • Mouse Swiss Prot No:

    P52332

  • Specificity:

    JAK1 Polyclonal Antibody detects endogenous levels of JAK1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    JAK1; JAK1A; JAK1B; Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1

  • MolecularWeight(Da):

    131957

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specif

  • Subcellular Location:

    nucleus,cytoplasm,cytosol,cytoskeleton,focal adhesion,endomembrane system,membrane,extrinsic component of cytoplasmic side of plasma membrane,

  • Expression:

    Brain,Colon tumor,Kidney,Lung,Uterus,

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Catalog Number

  • Amount:100ul
  • Price:225$

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JAK1 Polyclonal Antibody | EnoGene Biotech Co. Ltd