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ITPK1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72416

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ITPK1. AA range:81-130

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ITPK1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Western blot analysis of lysates from HeLa, HepG2, and Jurkat cells, using ITPK1 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    inositol-tetrakisphosphate 1-kinase(ITPK1) Homo sapiens This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016],

  • Protein Name:

    Inositol-tetrakisphosphate 1-kinase

  • Human Gene Id:

    3705

  • Human Swiss Prot No:

    Q13572

  • Mouse Gene Id:

    217837

  • Mouse Swiss Prot No:

    Q8BYN3

  • Specificity:

    ITPK1 Polyclonal Antibody detects endogenous levels of ITPK1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ITPK1; Inositol-tetrakisphosphate 1-kinase; Inositol 1; 3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase

  • MolecularWeight(Da):

    45621

  • Observed Band(KD):

    50

  • Function:

    catalytic activity:ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,catalytic activity:ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.,catalytic activity:ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.,caution:PubMed:11533064 detected some protein kinase activity and ability to phosphorylate transcription factors c-jun/JUN and ATF2. However, PubMed:15762844 showed that it does not have protein kinase activity.,cofactor:Binds 2 magnesium ions per subunit.,function:Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-

  • Subcellular Location:

    intracellular,cytosol,apical plasma membrane,

  • Expression:

    Brain,Eye,Muscle,

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Catalog Number

  • Amount:100ul
  • Price:225$

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