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IRTKS Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72411

  • Amount:

    100ul

  • Molecular Weight:

    56883Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human BAIAP2L1. AA range:111-160

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using IRTKS Polyclonal Antibody diluted at 1:2000.

  • Gene Name:

    BAIAP2L1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

  • Human Gene Id:

    55971

  • Human Swiss Prot No:

    Q9UHR4

  • Mouse Gene Id:

    66898

  • Mouse Swiss Prot No:

    Q9DBJ3

  • Rat Gene Id:

    304282

  • Rat Swiss Prot No:

    Q3KR97

  • Specificity:

    IRTKS Polyclonal Antibody detects endogenous levels of IRTKS protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    BAIAP2L1; IRTKS; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate

  • Observed Band(KD):

    57

  • Background:

    This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal fo

  • Function:

    domain:The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation.,function:May function as adapter protein (Potential). Involved in the formation of clusters of actin bundles.,PTM:Phosphorylated on tyrosine in response to insulin.,similarity:Contains 1 IMD (IRSp53/MIM homology) domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with RAC1. Binds to F-actin.,

  • Subcellular Location:

    Cytoplasm, cytoskeleton . Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

  • Expression:

    Adrenal gland,Epithelium,Lung,Placenta,

  • Western blot analysis of lysates from HepG2 cells, using BAIAP2L1 Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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IRTKS Polyclonal Antibody | EnoGene Biotech Co. Ltd