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Cell Signal Transduction Research Antibodies
OATP-C Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight102251 Da
Protein NameSerine/threonine-protein kinase/endoribonuclease IRE2
Human Gene Id10595
Human Swiss Prot NoQ76MJ5
Mouse Gene Id26918
Mouse Swiss Prot NoQ9Z2E3
SpecificityIRE1α/β Polyclonal Antibody detects endogenous levels of IRE1α/β protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameERN2; IRE2; Serine/threonine-protein kinase/endoribonuclease IRE2; Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; hIRE2p; Ire1-beta; IRE1b
Functioncatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,
Subcellular Locationintegral component of membrane,IRE1-TRAF2-ASK1 complex,
ExpressionFetal brain,Fetal lung fibroblast,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human ERN2. AA range:841-890
Gene NameERN2
DilutionImmunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundcatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,
Conjugated Antibody
This product is also available conjugated. Format: E20-72394-Conjugate. Price: $485 / Size: 100μl.
E20-72394-FITC$485 / 100μlE20-72394-Biotin$485 / 100μlE20-72394-HRP$485 / 100μlE20-72394-AP$485 / 100μlE20-72394-AF350$485 / 100μlE20-72394-AF405M$485 / 100μlE20-72394-AF488$485 / 100μlE20-72394-AF514$485 / 100μlE20-72394-AF532$485 / 100μlE20-72394-AF555$485 / 100μlE20-72394-AF568$485 / 100μlE20-72394-AF405S$485 / 100μlE20-72394-AF405L$485 / 100μlE20-72394-AF546$485 / 100μlE20-72394-AF594$485 / 100μlE20-72394-AF610$485 / 100μlE20-72394-AF635$485 / 100μlE20-72394-AF647$485 / 100μlE20-72394-AF680$485 / 100μlE20-72394-AF700$485 / 100μlE20-72394-AF750$485 / 100μlE20-72394-AF790$485 / 100μlE20-72394-APC$485 / 100μlE20-72394-PE$485 / 100μlE20-72394-Cy3$485 / 100μlE20-72394-Cy5$485 / 100μlE20-72394-Cy5.5$485 / 100μlE20-72394-Cy7$485 / 100μlE20-72394-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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