IRAK-M Polyclonal Antibody

Name: IRAK-M Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-72393
Price: 225 USD
Availability: InStock

E20-72393Cite ID: EN0052526Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight67753DaObserved Band:68KD

Protein NameInterleukin-1 receptor-associated kinase 3

Human Gene Id11213

Human Swiss Prot NoQ9Y616

Mouse Swiss Prot NoQ8K4B2

SpecificityIRAK-M Polyclonal Antibody detects endogenous levels of IRAK-M protein

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameIRAK3; Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M

Functioncatalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in PubMed:10383454, while other authors describe this as an inactive kinase.,cofactor:Magnesium.,disease:Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.,function:Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.,similarity:Belongs to the protein kinase superfamily. TK

Subcellular Locationnucleus,cytoplasm,

ExpressionPeripheral blood lymphocyte,Placenta,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human IRAK3. AA range:491-540

Gene NameIRAK3

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Backgroundinterleukin 1 receptor associated kinase 3(IRAK3) Homo sapiens This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-72393-Conjugate. Price: $485 / Size: 100μl.

E20-72393-FITC$485 / 100μlE20-72393-Biotin$485 / 100μlE20-72393-HRP$485 / 100μlE20-72393-AP$485 / 100μlE20-72393-AF350$485 / 100μlE20-72393-AF405M$485 / 100μlE20-72393-AF488$485 / 100μlE20-72393-AF514$485 / 100μlE20-72393-AF532$485 / 100μlE20-72393-AF555$485 / 100μlE20-72393-AF568$485 / 100μlE20-72393-AF405S$485 / 100μlE20-72393-AF405L$485 / 100μlE20-72393-AF546$485 / 100μlE20-72393-AF594$485 / 100μlE20-72393-AF610$485 / 100μlE20-72393-AF635$485 / 100μlE20-72393-AF647$485 / 100μlE20-72393-AF680$485 / 100μlE20-72393-AF700$485 / 100μlE20-72393-AF750$485 / 100μlE20-72393-AF790$485 / 100μlE20-72393-APC$485 / 100μlE20-72393-PE$485 / 100μlE20-72393-Cy3$485 / 100μlE20-72393-Cy5$485 / 100μlE20-72393-Cy5.5$485 / 100μlE20-72393-Cy7$485 / 100μlE20-72393-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.