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IRAK-2 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72392Amount:
100ulMolecular Weight:
69433DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
Synthesized peptide derived from the Internal region of human IRAK-2.Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using IRAK-2 Polyclonal Antibody diluted at 1:2000
Gene Name:
IRAK2Dilution:
WB 1:500-2000;IHC-p 1:50-300Protein Name:
Interleukin-1 receptor-associated kinase-like 2Human Gene Id:
3656Human Swiss Prot No:
O43187Mouse Swiss Prot No:
Q8CFA1Specificity:
IRAK-2 Polyclonal Antibody detects endogenous levels of IRAK-2 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
IRAK2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2Observed Band(KD):
70Background:
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008],Function:
caution:Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.,tissue specificity:Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukoSubcellular Location:
nucleus,cytoplasm,cytosol,plasma membrane,endosome membrane,Expression:
Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
- Western Blot analysis of 293 cells using IRAK-2 Polyclonal Antibody diluted at 1:2000
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