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IP3R-I Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72381

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human InsP3R1. AA range:1566-1615

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ITPR1

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using InsP3R1 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    inositol 1,4,5-trisphosphate receptor type 1(ITPR1) Homo sapiens This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009],

  • Protein Name:

    Inositol 1,4,5-trisphosphate receptor type 1

  • Human Gene Id:

    3708

  • Human Swiss Prot No:

    Q14643

  • Mouse Gene Id:

    16438

  • Mouse Swiss Prot No:

    P11881

  • Rat Gene Id:

    25262

  • Rat Swiss Prot No:

    P29994

  • Specificity:

    IP3R-I Polyclonal Antibody detects endogenous levels of IP3R-I protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ITPR1; INSP3R1; Inositol 1; 4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor

  • MolecularWeight(Da):

    313945

  • Function:

    alternative products:There is a combination of three alternatively spliced domains at site SI, SIII and site SII (A and C). Experimental confirmation may be lacking for some isoforms,disease:Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.,domain:The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has

  • Subcellular Location:

    nuclear inner membrane,nucleolus,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,calcineurin complex,postsynaptic density,membrane,integral component of membrane,sarcoplasmic reticulum,platelet

  • Expression:

    Brain,Epithelium,Liver,Myeloid,T-cell,Uterus,

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Catalog Number

  • Amount:100ul
  • Price:225$

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IP3R-I Polyclonal Antibody | EnoGene Biotech Co. Ltd