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IP3KA Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72380

  • Amount:

    100ul

  • Molecular Weight:

    51009Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human IP3KA. AA range:396-445

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using IP3KA Polyclonal Antibody

  • Gene Name:

    ITPKA

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

  • Protein Name:

    Inositol-trisphosphate 3-kinase A

  • Human Gene Id:

    3706

  • Human Swiss Prot No:

    P23677

  • Mouse Gene Id:

    228550

  • Mouse Swiss Prot No:

    Q8R071

  • Rat Gene Id:

    81677

  • Rat Swiss Prot No:

    P17105

  • Specificity:

    IP3KA Polyclonal Antibody detects endogenous levels of IP3KA protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ITPKA; Inositol-trisphosphate 3-kinase A; Inositol 1; 4,5-trisphosphate 3-kinase A; IP3 3-kinase A; IP3K A; InsP 3-kinase A

  • Observed Band(KD):

    52

  • Background:

    Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011],

  • Function:

    catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,enzyme regulation:IP3K is activated by calmodulin.,similarity:Belongs to the inositol phosphokinase (IPK) family.,

  • Subcellular Location:

    Cytoplasm, cytoskeleton .

  • Expression:

    Expressed in brain.Products Images

  • Western blot analysis of lysates from HUVEC cells, using IP3KA Antibody. The lane on the right is blocked with the synthesized peptide.

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