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IP Receptor Polyclonal Antibody
Datasheet
Catalog Number:
E20-72378Amount:
100ulSwiss-Prot No.:
P43119Molecular Weight:
40.9kd Observed Band 45kdApplications:
WB,IF/ICC,ELISAReactivity:
HumanPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Prostacyclin Receptor. AA range:198-247Specificity/Sensitivity:
IP Receptor Polyclonal Antibody detects endogenous levels of IP Receptor protein.Storage/Stability:
-20°C/1 yearSource:
RabbitGene Name:
PTGIRDilution:
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
- Immunofluorescence analysis of LOVO cells, using Prostacyclin Receptor Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
prostaglandin I2 (prostacyclin) receptor (IP)(PTGIR) Homo sapiens The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008],Gene ID:
5739Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azideFunction:
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.,PTM:Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectorsadenylyl cyclase and phospholipase C.,PTM:Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.,similarity:Belongs to the G-protein coupled receptor 1 family.,
- Western blot analysis of lysates from K562 cells, using Prostacyclin Receptor Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from HUVECcells using Prostacyclin Receptor antibody.
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