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Involucrin Polyclonal Antibody
Datasheet
Catalog Number:
E20-72377Amount:
100ulMolecular Weight:
68468DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Involucrin. AA range:536-585Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using Involucrin Polyclonal Antibody
Gene Name:
IVLDilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.Protein Name:
InvolucrinHuman Gene Id:
3713Human Swiss Prot No:
P07476Mouse Swiss Prot No:
P48997Specificity:
Involucrin Polyclonal Antibody detects endogenous levels of Involucrin protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
IVL; InvolucrinObserved Band(KD):
68Background:
involucrin(IVL) Homo sapiens Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008],Function:
function:Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.,PTM:Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.,similarity:Belongs to the involucrin family.,subcellular location:Constituent of the scaffolding of the cornified envelope.,subunit:Directly or indirectly cross-linked to cornifelin (CNFN).,tissue specificity:Keratinocytes of epidermis and other stratified squamous epithelia.,Subcellular Location:
Cytoplasm. Constituent of the scaffolding of the cornified envelope.Expression:
Keratinocytes of epidermis and other stratified squamous epithelia.Products Images
- Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Involucrin Antibody. The picture on the right is blocked with the synthesized peptide.
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