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Integrin β2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72369

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CD18/ITGB2. AA range:720-769

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ITGB2

  • Dilution:

    Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Immunofluorescence analysis of HeLa cells, using CD18/ITGB2 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    integrin subunit beta 2(ITGB2) Homo sapiens This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

  • Protein Name:

    Integrin beta-2

  • Human Gene Id:

    3689

  • Human Swiss Prot No:

    P05107

  • Mouse Gene Id:

    16414

  • Mouse Swiss Prot No:

    P11835

  • Specificity:

    Integrin β2 Polyclonal Antibody detects endogenous levels of Integrin β2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18

  • MolecularWeight(Da):

    84782

  • Function:

    disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on S

  • Subcellular Location:

    plasma membrane,integrin complex,cell surface,membrane,integrin alphaL-beta2 complex,receptor complex,extracellular exosome,extracellular vesicle,

  • Expression:

    Blood,Liver,Muscle,Plasma,Spleen,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Integrin β2 Polyclonal Antibody | EnoGene Biotech Co. Ltd