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Integrin αE Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72364

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Integrin alphaE. AA range:131-180

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ITGAE

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Western blot analysis of lysate from HepG2 cells, using Integrin αE antibody.

  • Background:

    integrin subunit alpha E(ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Integrin alpha-E

  • Human Gene Id:

    3682

  • Human Swiss Prot No:

    P38570

  • Mouse Swiss Prot No:

    Q60677

  • Specificity:

    Integrin αE Polyclonal Antibody detects endogenous levels of Integrin αE protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ITGAE; Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD antigen CD103

  • MolecularWeight(Da):

    130089

  • Observed Band(KD):

    130

  • Function:

    domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.,induction:Integrin alpha-E/beta-7 is induced by TGFB1.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 5 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.,tissue specificity:Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.,

  • Subcellular Location:

    plasma membrane,integrin complex,external side of plasma membrane,

  • Expression:

    Fetal kidney,Leukemia,Lymphocyte,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Integrin αE Polyclonal Antibody | EnoGene Biotech Co. Ltd