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Integrin α4 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72363

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Integrin alpha4. AA range:983-1032

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ITGA4

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Western blot analysis of lysates from Jurkat cells, treated with PMA 125ng/ml 30', using Integrin alpha4 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    integrin subunit alpha 4(ITGA4) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

  • Protein Name:

    Integrin alpha-4

  • Human Gene Id:

    3676

  • Human Swiss Prot No:

    P13612

  • Mouse Gene Id:

    16401

  • Mouse Swiss Prot No:

    Q00651

  • Specificity:

    Integrin α4 Polyclonal Antibody detects endogenous levels of Integrin α4 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ITGA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD antigen CD49d

  • MolecularWeight(Da):

    115333

  • Observed Band(KD):

    115

  • Function:

    domain:The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.,function:Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.,PTM:Phosphorylation on Ser-1027 inhibits PXN binding.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit

  • Subcellular Location:

    plasma membrane,focal adhesion,integrin complex,cell surface,membrane,integral component of membrane,integrin alpha4-beta7 complex,extracellular exosome,

  • Expression:

    Lymph,Peripheral blood,Prostate,Spleen,Testis,

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Catalog Number

  • Amount:100ul
  • Price:225$

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