ILT-3 Polyclonal Antibody

Name: ILT-3 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-72348
Price: 225 USD
Availability: InStock

E20-72348Cite ID: EN0052481Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight49298Da

Protein NameLeukocyte immunoglobulin-like receptor subfamily B member 4

Human Gene Id11006

Human Swiss Prot NoQ8NHJ6

Mouse Swiss Prot NoQ64281

SpecificityILT-3 Polyclonal Antibody detects endogenous levels of ILT-3 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameLILRB4; ILT3; LIR5; Leukocyte immunoglobulin-like receptor subfamily B member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18;

Functiondomain:Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.,induction:Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells.,PTM:Phosphorylated.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Ligand binding

Subcellular Locationplasma membrane,integral component of membrane,extracellular exosome,

ExpressionBrain,Monocyte,Peripheral blood leukocyte,Placenta,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human LILRB4. AA range:201-250

Gene NameLILRB4

DilutionImmunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Backgroundleukocyte immunoglobulin like receptor B4(LILRB4) Homo sapiens This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-72348-Conjugate. Price: $485 / Size: 100μl.

E20-72348-FITC$485 / 100μlE20-72348-Biotin$485 / 100μlE20-72348-HRP$485 / 100μlE20-72348-AP$485 / 100μlE20-72348-AF350$485 / 100μlE20-72348-AF405M$485 / 100μlE20-72348-AF488$485 / 100μlE20-72348-AF514$485 / 100μlE20-72348-AF532$485 / 100μlE20-72348-AF555$485 / 100μlE20-72348-AF568$485 / 100μlE20-72348-AF405S$485 / 100μlE20-72348-AF405L$485 / 100μlE20-72348-AF546$485 / 100μlE20-72348-AF594$485 / 100μlE20-72348-AF610$485 / 100μlE20-72348-AF635$485 / 100μlE20-72348-AF647$485 / 100μlE20-72348-AF680$485 / 100μlE20-72348-AF700$485 / 100μlE20-72348-AF750$485 / 100μlE20-72348-AF790$485 / 100μlE20-72348-APC$485 / 100μlE20-72348-PE$485 / 100μlE20-72348-Cy3$485 / 100μlE20-72348-Cy5$485 / 100μlE20-72348-Cy5.5$485 / 100μlE20-72348-Cy7$485 / 100μlE20-72348-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.