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ILKAP Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72347

  • Amount:

    100ul

  • Molecular Weight:

    42907Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ILKAP. AA range:41-90

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using ILKAP Polyclonal Antibody

  • Gene Name:

    ILKAP

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Integrin-linked kinase-associated serine/threonine phosphatase 2C

  • Human Gene Id:

    80895

  • Human Swiss Prot No:

    Q9H0C8

  • Mouse Gene Id:

    67444

  • Mouse Swiss Prot No:

    Q8R0F6

  • Rat Gene Id:

    64538

  • Rat Swiss Prot No:

    Q9Z1Z6

  • Specificity:

    ILKAP Polyclonal Antibody detects endogenous levels of ILKAP protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ILKAP; Integrin-linked kinase-associated serine/threonine phosphatase 2C; ILKAP

  • Observed Band(KD):

    45

  • Background:

    The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.,induction:Inhibited rather than stimulated by Magnesium.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.,tissue specificity:Widely expressed. Highest levels expressed in striated muscle. Muc

  • Subcellular Location:

    Cytoplasm .

  • Expression:

    Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.Products Images

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using ILKAP Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

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ILKAP Polyclonal Antibody | EnoGene Biotech Co. Ltd