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IL-8 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72343

  • Amount:

    100ul

  • Molecular Weight:

    11098Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human IL-8. AA range:19-68

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using IL-8 Polyclonal Antibody

  • Gene Name:

    IL8

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Interleukin-8

  • Human Gene Id:

    3576

  • Human Swiss Prot No:

    P10145

  • Specificity:

    IL-8 Polyclonal Antibody detects endogenous levels of IL-8 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    IL8; CXCL8; Interleukin-8; IL-8; C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activati

  • Observed Band(KD):

    8

  • Background:

    The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008],

  • Function:

    function:IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.,online information:Interleukin-8 entry,PTM:Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homodimer.,

  • Subcellular Location:

    Secreted.

  • Expression:

    Chronic myeloid leukemia cell,Kidney,Lung,Lung carcinoma,Neutrophil,PeripheProducts Images

  • Immunohistochemistry analysis of IL-8 antibody in paraffin-embedded human lung carcinoma tissue.

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