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IL-4Rα Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72337

  • Amount:

    100ul

  • Molecular Weight:

    89658Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human IL-4R/CD124. AA range:463-512

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using IL-4Rα Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    IL4R

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Interleukin-4 receptor subunit alpha

  • Human Gene Id:

    3566

  • Human Swiss Prot No:

    P24394

  • Mouse Gene Id:

    16190

  • Mouse Swiss Prot No:

    P16382

  • Specificity:

    IL-4Rα Polyclonal Antibody detects endogenous levels of IL-4Rα protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    IL4R; IL4RA; 582J2.1; Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD antigen CD124

  • Observed Band(KD):

    90

  • Background:

    This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012],

  • Function:

    domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The extracellular domain represents the IL4 binding protein (IL4BP).,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cel

  • Subcellular Location:

    Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

  • Expression:

    Isoform 1 and isoform 2 are highly expressed in activated T-cells.Products Images

  • Western blot analysis of mouse-kidney 293T lysis using IL-4Rα antibody. Antibody was diluted at 1:2000

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