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IL-21 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72327Amount:
100ulMolecular Weight:
17923DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human IL21. AA range:91-140Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using IL-21 Polyclonal Antibody diluted at 1:500
Gene Name:
IL21Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.Protein Name:
Interleukin-21Human Gene Id:
59067Human Swiss Prot No:
Q9HBE4Mouse Gene Id:
60505Mouse Swiss Prot No:
Q9ES17Specificity:
IL-21 Polyclonal Antibody detects endogenous levels of IL-21 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
IL21; Interleukin-21; IL-21; Za11Observed Band(KD):
18Background:
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],Function:
function:Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.,similarity:Belongs to the IL-15/IL-21 family.,tissue specificity:Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.,Subcellular Location:
Secreted .Expression:
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.Products Images
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