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IL-10Rα Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72308

  • Amount:

    100ul

  • Molecular Weight:

    62904Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human IL-10R alpha. AA range:462-511

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using IL-10Rα Polyclonal Antibody

  • Gene Name:

    IL10RA

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Interleukin-10 receptor subunit alpha

  • Human Gene Id:

    3587

  • Human Swiss Prot No:

    Q13651

  • Mouse Swiss Prot No:

    Q61727

  • Specificity:

    IL-10Rα Polyclonal Antibody detects endogenous levels of IL-10Rα protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    IL10RA; IL10R; Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD antigen CD210

  • Observed Band(KD):

    63

  • Background:

    The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009],

  • Function:

    function:Receptor for IL10; binds IL10 with a high affinity.,similarity:Belongs to the type II cytokine receptor family.,tissue specificity:Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.,

  • Subcellular Location:

    Cell membrane ; Single-pass type I membrane protein. Cytoplasm .

  • Expression:

    Primarily expressed in hematopoetic cells including B-cells, T-cells, NK cells, monocytes and macrophages. Not expressed in non-hematopoetic cells such as fibroblasts or endothelial cells.Products Images

  • Immunofluorescence analysis of HepG2 cells, using IL-10R alpha Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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IL-10Rα Polyclonal Antibody | EnoGene Biotech Co. Ltd