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IFI-16 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72274

  • Amount:

    100ul

  • Molecular Weight:

    88256Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human IFI16. AA range:731-780

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    IFI16

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Western blot analysis of lysates from HeLa and HepG2 cells, using IFI16 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    interferon gamma inducible protein 16(IFI16) Homo sapiens This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011],

  • Protein Name:

    Gamma-interferon-inducible protein 16

  • Human Gene Id:

    3428

  • Human Swiss Prot No:

    Q16666

  • Specificity:

    IFI-16 Polyclonal Antibody detects endogenous levels of IFI-16 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    IFI16; IFNGIP1; Gamma-interferon-inducible protein 16; Ifi-16; Interferon-inducible myeloid differentiation transcriptional activator

  • Observed Band(KD):

    88

  • Function:

    function:May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells.,induction:Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. In HL-60 cells, maximum induction by gamma-interferon occurs within 12 hours whereas, for alpha-interferon, only 10-fold induction was observed after 36 hours. Induced in vitro by dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3.,PTM:Isoform 3 seems to show a minor degree of complex carbohydrate addition.,PTM:Phosphorylated on Ser and Thr.,sequence caution:Intron retention.,similarity:Belongs to the HIN-200 family.,

  • Subcellular Location:

    nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,membrane,nuclear speck,

  • Expression:

    Bone marrow,Brain,Epithelium,Hippocampus,T-cell,Uterus,

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Catalog Number

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IFI-16 Polyclonal Antibody | EnoGene Biotech Co. Ltd