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HSC 70 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72231

  • Amount:

    100ul

  • Molecular Weight:

    70898Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human HSC 70. AA range:202-251

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using HSC 70 Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    HSPA8

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Heat shock cognate 71 kDa protein

  • Human Gene Id:

    3312

  • Human Swiss Prot No:

    P11142

  • Mouse Gene Id:

    15481

  • Mouse Swiss Prot No:

    P63017

  • Rat Gene Id:

    24468

  • Rat Swiss Prot No:

    P63018

  • Specificity:

    HSC 70 Polyclonal Antibody detects endogenous levels of HSC 70 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    HSPA8; HSC70; HSP73; HSPA10; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8

  • Observed Band(KD):

    70

  • Background:

    This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

  • Function:

    function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,

  • Subcellular Location:

    Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.

  • Expression:

    Ubiquitous.

  • Western Blot analysis of HepG2 cells using HSC 70 Polyclonal Antibody diluted at 1:2000

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Catalog Number

  • Amount:100ul
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HSC 70 Polyclonal Antibody | EnoGene Biotech Co. Ltd