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Hrs Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72228

  • Amount:

    100ul

  • Molecular Weight:

    86192Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human HRS. AA range:301-350

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Hrs Polyclonal Antibody diluted at 1:500

  • Gene Name:

    HGS

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Hepatocyte growth factor-regulated tyrosine kinase substrate

  • Human Gene Id:

    9146

  • Human Swiss Prot No:

    O14964

  • Mouse Gene Id:

    15239

  • Mouse Swiss Prot No:

    Q99LI8

  • Rat Gene Id:

    56084

  • Rat Swiss Prot No:

    Q9JJ50

  • Specificity:

    Hrs Polyclonal Antibody detects endogenous levels of Hrs protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    HGS; HRS; Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110

  • Observed Band(KD):

    80

  • Background:

    The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010],

  • Function:

    domain:Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix.,function:Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the

  • Subcellular Location:

    Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome, multivesicular body membrane ; Peripheral membrane protein . Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. .

  • Expression:

    Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.

  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HRS Antibody. The picture on the right is blocked with the synthesized peptide.

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