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HNK-1ST Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72191

  • Amount:

    100ul

  • Molecular Weight:

    (Da):42207

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CHST10. AA range:191-240

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using HNK-1ST Polyclonal Antibody

  • Gene Name:

    CHST10

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Carbohydrate sulfotransferase 10

  • Human Gene Id:

    9486

  • Human Swiss Prot No:

    O43529

  • Mouse Gene Id:

    98388

  • Mouse Swiss Prot No:

    Q6PGK7

  • Rat Gene Id:

    140568

  • Rat Swiss Prot No:

    O54702

  • Specificity:

    HNK-1ST Polyclonal Antibody detects endogenous levels of HNK-1ST protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CHST10; Carbohydrate sulfotransferase 10; HNK-1 sulfotransferase; HNK-1ST; HNK1ST; HuHNK-1ST

  • Observed Band(KD):

    48

  • Background:

    This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011],

  • Function:

    function:Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.,similarity:Belongs to the sulfotransferase 2 family.,tissue specificity:In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at high

  • Subcellular Location:

    Golgi apparatus membrane ; Single-pass type II membrane protein .

  • Expression:

    In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at higher level in the frontal lobe.

  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CHST10 Antibody. The picture on the right is blocked with the synthesized peptide.

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HNK-1ST Polyclonal Antibody | EnoGene Biotech Co. Ltd