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HMG-2 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72187Amount:
100ulMolecular Weight:
24034DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human HMGB2. AA range:131-180Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using HMG-2 Polyclonal Antibody
Gene Name:
HMGB2Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
High mobility group protein B2Human Gene Id:
3148Human Swiss Prot No:
P26583Mouse Gene Id:
97165Mouse Swiss Prot No:
P30681Rat Gene Id:
29395Rat Swiss Prot No:
P52925Specificity:
HMG-2 Polyclonal Antibody detects endogenous levels of HMG-2 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
HMGB2; HMG2; High mobility group protein B2; High mobility group protein 2; HMG-2Observed Band(KD):
27Background:
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008],Function:
function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly interacts with SET.,Subcellular Location:
Nucleus . Chromosome . Cytoplasm . Secreted . In basal state predominantly nuclear. .Expression:
Expressed in gastric and intestinal tissues (at protein level).
- Western blot analysis of lysates from COLO205 cells, using HMGB2 Antibody. The lane on the right is blocked with the synthesized peptide.
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