Histone H4 rabbit pAbAntibody

Name: Histone H4 rabbit pAbAntibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-72171
Price: 225 USD
Availability: InStock

E20-72171Cite ID: EN0052304Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight11330Da

Protein NameHistone H4 Polyclonal Antibody

Human Gene Id121504

Human Swiss Prot NoP62805

Mouse Gene Id100041230

Mouse Swiss Prot NoP62806

Rat Gene Id100360950

Rat Swiss Prot NoP62804

SpecificityThis antibody detects endogenous levels of Human,Mouse,Rat Histone H4 Polyclonal Antibody

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameHistone H4

Observed Band(KD)14

FunctionDNA packaging, chromatin organization, chromatin assembly or disassembly, nucleosome assembly, intracellular signaling cascade, second-messenger-mediated signaling, chromatin assembly, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, nucleosome organization, macromolecular complex subunit organization, negative regulation of cell differentiation, regulation of myeloid cell differentiation, negative regulation of myeloid cell differentiation, regulation of megakaryocyte differentiation, negative regulation of megakaryocyte differentiation, phosphoinositide-mediated signaling, chromosome organization, macromolecular complex assembly, protein-DNA complex assembly,

PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

ImmunogenSynthesized peptide derived from human Histone H4 Polyclonal Antibody

Gene NameHIST1H4A H4/A H4FA; HIST1H4B H4/I H4FI; HIST1H4C H4/G H4FG; HIST1H4D H4/B H4FB; HIST1H4E H4/J H4FJ; HIST1H4F H4/C H4FC; HIST1H4H H4/H H4FH; HIST1H4I H4/M H4FM; HIST1H4J H4/E H4FE; HIST1H4K H4/D H4FD; HIST1H4L H4/K H4FK; HIST2H4A H4/N H4F2 H4FN HIST2H4; HIST2H4B H4/O H4FO; HIST4H4

DilutionWB 1:1000-2000 ELISA 1:5000-20000

Backgroundfunction:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Acetylation at Lys-6, Lys-9, Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.,PTM:Citrullination at Arg-4 by PADI4 impairs methylation.,PTM:Monomethylated, dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.,PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.,PTM:Sumoylated, which is associated with transcriptional repression.,PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.,similarity:Belongs to the histone H4 family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-72171-Conjugate. Price: $485 / Size: 100μl.

E20-72171-FITC$485 / 100μlE20-72171-Biotin$485 / 100μlE20-72171-HRP$485 / 100μlE20-72171-AP$485 / 100μlE20-72171-AF350$485 / 100μlE20-72171-AF405M$485 / 100μlE20-72171-AF488$485 / 100μlE20-72171-AF514$485 / 100μlE20-72171-AF532$485 / 100μlE20-72171-AF555$485 / 100μlE20-72171-AF568$485 / 100μlE20-72171-AF405S$485 / 100μlE20-72171-AF405L$485 / 100μlE20-72171-AF546$485 / 100μlE20-72171-AF594$485 / 100μlE20-72171-AF610$485 / 100μlE20-72171-AF635$485 / 100μlE20-72171-AF647$485 / 100μlE20-72171-AF680$485 / 100μlE20-72171-AF700$485 / 100μlE20-72171-AF750$485 / 100μlE20-72171-AF790$485 / 100μlE20-72171-APC$485 / 100μlE20-72171-PE$485 / 100μlE20-72171-Cy3$485 / 100μlE20-72171-Cy5$485 / 100μlE20-72171-Cy5.5$485 / 100μlE20-72171-Cy7$485 / 100μlE20-72171-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.