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Histone deacetylase 9 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72149Amount:
100ulMolecular Weight:
111297DaApplications:
WB;IHC-p;IF/ICC;ELISAReactivity:
Human;Rat;Mouse;Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human HDAC9. AA range:1017-1066Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using Histone deacetylase 9 Polyclonal Antibody diluted at 1:1000
Gene Name:
HDAC9Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
Histone deacetylase 9Human Gene Id:
9734Human Swiss Prot No:
Q9UKV0-5,6,7Specificity:
Histone deacetylase 9 Polyclonal Antibody detects endogenous levels of Histone deacetylase 9 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
Histone deacetylase 9; HD9; Histone deacetylase 7B; HD7; HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITRObserved Band(KD):
110Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 9 encoded by HDAC9 has sequence homology to members of the histone deacetylase family. HDAC9 is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.Subcellular Location:
Nucleus .Expression:
Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
- Western Blot analysis of HepG2 cells using Histone deacetylase 9 Polyclonal Antibody diluted at 1:1000
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