World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Hec1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight73913 Da
Protein NameKinetochore protein NDC80 homolog
Human Gene Id10403
Human Swiss Prot NoO14777
Mouse Gene Id67052
Mouse Swiss Prot NoQ9D0F1
SpecificityHec1 Polyclonal Antibody detects endogenous levels of Hec1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNDC80; HEC; HEC1; KNTC2; Kinetochore protein NDC80 homolog; Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC
Observed Band(KD)73
Functiondevelopmental stage:Expression peaks in mitosis.,function:Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.,PTM:Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.,similarity:Belongs to the NDC80/HEC1 family.,subcellular location:Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.,subunit:Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by pa
Subcellular Locationchromosome, centromeric region,kinetochore,condensed chromosome kinetochore,condensed nuclear chromosome outer kinetochore,nucleus,cytosol,membrane,Ndc80 complex,
ExpressionBladder,Brain,Epithelium,Lymph,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human KNTC2. AA range:351-400
Gene NameNDC80
DilutionWestern Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundNDC80, kinetochore complex component(NDC80) Homo sapiens This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-72121-Conjugate. Price: $485 / Size: 100μl.
E20-72121-FITC$485 / 100μlE20-72121-Biotin$485 / 100μlE20-72121-HRP$485 / 100μlE20-72121-AP$485 / 100μlE20-72121-AF350$485 / 100μlE20-72121-AF405M$485 / 100μlE20-72121-AF488$485 / 100μlE20-72121-AF514$485 / 100μlE20-72121-AF532$485 / 100μlE20-72121-AF555$485 / 100μlE20-72121-AF568$485 / 100μlE20-72121-AF405S$485 / 100μlE20-72121-AF405L$485 / 100μlE20-72121-AF546$485 / 100μlE20-72121-AF594$485 / 100μlE20-72121-AF610$485 / 100μlE20-72121-AF635$485 / 100μlE20-72121-AF647$485 / 100μlE20-72121-AF680$485 / 100μlE20-72121-AF700$485 / 100μlE20-72121-AF750$485 / 100μlE20-72121-AF790$485 / 100μlE20-72121-APC$485 / 100μlE20-72121-PE$485 / 100μlE20-72121-Cy3$485 / 100μlE20-72121-Cy5$485 / 100μlE20-72121-Cy5.5$485 / 100μlE20-72121-Cy7$485 / 100μlE20-72121-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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