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HDAC8 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72120

  • Amount:

    100ul

  • Molecular Weight:

    ： 41758Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat；Monkey

  • Purification:

    ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    ： The antiserum was produced against synthesized peptide derived from human HDAC8. AA range:5-54

  • Source:

    ： Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using HDAC8 Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    ： HDAC8

  • Dilution:

    ： Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    ： Histone deacetylase 8

  • Human Gene Id:

    ： 55869

  • Human Swiss Prot No:

    ： Q9BY41

  • Mouse Gene Id:

    ： 70315

  • Mouse Swiss Prot No:

    ： Q8VH37

  • Rat Gene Id:

    ： 1.00912e+008

  • Rat Swiss Prot No:

    ： B1WC68

  • Specificity:

    ： HDAC8 Polyclonal Antibody detects endogenous levels of HDAC8 protein.

  • Formulation:

    ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    ： 1 mg/ml

  • Storage Stability:

    ： -20°C/1 year

  • Other Name:

    ： HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8

  • Observed Band(KD):

    ： 42

  • Background:

    ： histone deacetylase 8(HDAC8) Homo sapiens Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],

  • Function:

    ： catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,miscellaneous:Its activity is inhibited by trichostatin A (TSA) and butyrate, two well known histone deacetylase inhibitors.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subcellular location:Excluded from the nucleoli.,subunit:Interacts with PEPB2-MYH11, a f

  • Subcellular Location:

    ： Nucleus . Chromosome . Cytoplasm . Excluded from the nucleoli (PubMed:10748112). Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051). .

  • Expression:

    ： Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.

  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using HDAC8 Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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HDAC8 Polyclonal Antibody | EnoGene Biotech Co. Ltd