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HDAC1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72112

  • Amount:

    100ul

  • Molecular Weight:

    55103Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Ra

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human HDAC1. AA range:387-436

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using HDAC1 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    HDAC1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Histone deacetylase 1

  • Human Gene Id:

    3065

  • Human Swiss Prot No:

    Q13547

  • Mouse Gene Id:

    433759

  • Mouse Swiss Prot No:

    O09106

  • Rat Gene Id:

    297893

  • Rat Swiss Prot No:

    Q4QQW4

  • Specificity:

    HDAC1 Polyclonal Antibody detects endogenous levels of HDAC1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    HDAC1; RPD3L1; Histone deacetylase 1; HD1

  • Observed Band(KD):

    55

  • Background:

    Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.,PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates

  • Subcellular Location:

    Nucleus .

  • Expression:

    Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using HDAC1 Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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HDAC1 Polyclonal Antibody | EnoGene Biotech Co. Ltd